Study: Neurite imaging reveals microstructural variations in human cerebral cortical gray matter.
WU-Minn HCP Consortium Open Access Data Use Terms
1. I will not attempt to establish the identity of or attempt to contact any of the included human subjects.
2. I understand that under no circumstances will the code that would link these data to Protected Health Information be given to me, nor will any additional information about individual human subjects be released to me under these Open Access Data Use Terms.
3. I will comply with all relevant rules and regulations imposed by my institution. This may mean that I need my research to be approved or declared exempt by a committee that oversees research on human subjects, e.g. my IRB or Ethics Committee. The released HCP data are not considered de-identified, insofar as certain combinations of HCP Restricted Data (available through a separate process) might allow identification of individuals. Different committees operate under different national, state and local laws and may interpret regulations differently, so it is important to ask about this. If needed and upon request, the HCP will provide a certificate stating that you have accepted the HCP Open Access Data Use Terms.
4. I may redistribute original WU-Minn HCP Open Access data and any derived data as long as the data are redistributed under these same Data Use Terms.
5. I will acknowledge the use of WU-Minn HCP data and data derived from WU-Minn HCP data when publicly presenting any results or algorithms that benefitted from their use.
1. Papers, book chapters, books, posters, oral presentations, and all other printed and digital presentations of results derived from HCP data should contain the following wording in the acknowledgments section: "Data were provided [in part] by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University."
2. Authors of publications or presentations using WU-Minn HCP data should cite relevant publications describing the methods used by the HCP to acquire and process the data. The specific publications that are appropriate to cite in any given study will depend on what HCP data were used and for what purposes. An annotated and appropriately up-to-date list of publications that may warrant consideration is available at http://www.humanconnectome.org/about/acknowledgehcp.html
3. The WU-Minn HCP Consortium as a whole should not be included as an author of publications or presentations if this authorship would be based solely on the use of WU-Minn HCP data.
6. Failure to abide by these guidelines will result in termination of my privileges to access WU-Minn HCP data.
Something has gone wrong in the attempt to record your agreement to the Open Access data use terms. If you are using a ConnectomeDB account, we recommend following these steps:
- Log out of BALSA
- Log into your ConnectomeDB account
- Locate any HCP data set
- Click on the 'Data Use Terms Required' button
- Accept the terms
- Log back into BALSA
We apologize for any inconvenience.
Neurite imaging reveals microstructural variations in human cerebral cortical gray matter.
We present distinct patterns of neurite distribution in the human cerebral cortex using diffusion magnetic resonance imaging (MRI). ,We analyzed both high-resolution structural (T1w and T2w images) and diffusion MRI data in 505 subjects from the Human Connectome Project. Neurite distributions were evaluated using the neurite orientation dispersion and density imaging (NODDI) model, optimized for gray matter, and mapped onto the cortical surface using a method weighted towards the cortical mid-thickness to reduce partial volume effects. The estimated neurite density was high in both somatosensory and motor areas, early visual and auditory areas, and middle temporal area (MT), showing a strikingly similar distribution to myelin maps estimated from the T1w/T2w ratio. The estimated neurite orientation dispersion was particularly high in early sensory areas, which are known for dense tangential fibers and are classified as granular cortex by classical anatomists. Spatial gradients of these cortical neurite properties revealed transitions that colocalize with some areal boundaries in a recent multi-modal parcellation of the human cerebral cortex, providing mutually supportive evidence. Our findings indicate that analyzing the cortical gray matter neurite morphology using diffusion MRI and NODDI provides valuable information regarding cortical microstructure that is related to but complementary to myeloarchitecture.,
- Hikaru Fukutomi
- Matthew F. Glasser
- Hui Zhang
- Joonas A. Autio
- Timothy S. Coalson
- Tomohisa Okada
- Kaori Togashi
- David C. Van Essen
- Takuya Hayashi
- University College London
- Kyoto University
- Washington University in St. Louis