Study: Brain/MINDS Beyond Human Brain MRI Study: Multi-Site Harmonization
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License (CC BY-NC-SA 4.0)
You are free to:
- Share – copy and redistribute the material in any medium or format
- Adapt – remix, transform, and build upon the material
The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial – You may not use the material for commercial purposes.
- ShareAlike – If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
- No additional restrictions – You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
- You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
- No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
Go to https://creativecommons.org/licenses/by-nc-sa/4.0/ for more information.
Something has gone wrong in the attempt to record your agreement to the Open Access data use terms. If you are using a ConnectomeDB account, we recommend following these steps:
- Log out of BALSA
- Log into your ConnectomeDB account
- Locate any HCP data set
- Click on the 'Data Use Terms Required' button
- Accept the terms
- Log back into BALSA
We apologize for any inconvenience.
Brain/MINDS Beyond Human Brain MRI Project: A Protocol for Multi-level Harmonization across Brain Disorders Throughout the Lifespan
Psychiatric and neurological disorders are afflictions of the brain that can affect individuals throughout their lifespan. Many brain magnetic resonance imaging (MRI) studies have been conducted; however, imaging-based biomarkers are not yet well established for diagnostic and therapeutic use. This article describes an outline of the planned study, the Brain/MINDS Beyond human brain MRI project (BMB-HBM, FY2018 ~ FY2023), which aims to establish clinically-relevant imaging biomarkers with multi-site harmonization by collecting data from healthy traveling subjects (TS) at 13 research sites. Collection of data in psychiatric and neurological disorders across the lifespan is also scheduled at 13 sites, whereas designing measurement procedures, developing and analyzing neuroimaging protocols, and databasing are done at three research sites. A high-quality scanning protocol, Harmonization Protocol (HARP), was established for five high-quality 3T scanners to obtain multimodal brain images including T1 and T2-weighted, resting-state and task functional and diffusion-weighted MRI. Data are preprocessed and analyzed using approaches developed by the Human Connectome Project. Preliminary results in 30 TS demonstrated cortical thickness, myelin, functional connectivity measures are comparable across 5 scanners, suggesting sensitivity to subject-specific connectome. A total of 75 TS and more than two thousand patients with various psychiatric and neurological disorders are scheduled to participate in the project, allowing a mixed model statistical harmonization. The HARP protocols are publicly available online, and all the imaging, demographic and clinical information, harmonizing database will also be made available by 2024. To the best of our knowledge, this is the first project to implement a prospective, multi-level harmonization protocol with multi-site TS data. It explores intractable brain disorders across the lifespan and may help to identify the disease-specific pathophysiology and imaging biomarkers for clinical practice.
- Koke S
- Tanaka SC
- Okada T
- Aso T
- Yamashita A
- Yamashita O
- Asano M
- Maikusa N
- Morita K
- Okada N
- Fukunaga M
- Uematsu A
- Togo H
- Miyazaki A
- Murata K
- Urushibata Y
- Autio J
- Ose T
- Yoshimoto J
- Araki T
- Glasser MF
- Van Essen DC
- Maruyama M
- Sadato N
- Kawato M
- Kasai K
- Okamoto Y
- Hanakawa T
- Hayashi T
- Tamagawa University Brain Science Institute
- Washington University in St. Louis
- Advanced Telecommunications Research Institutes International (ATR)
- Hiroshima University
- Siemens Healthcare K.K, Tokyo, JP
- National Center of Neurology and Psychiatry, Tokyo, JP
- Kyoto University
- University of Tokyo
- National Institute for Physiological Sciences, Okazaki, JP