Study: Receptor architecture of macaque inferior parietal lobe
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License (CC BY-NC-SA 4.0)
You are free to:
- Share – copy and redistribute the material in any medium or format
- Adapt – remix, transform, and build upon the material
The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial – You may not use the material for commercial purposes.
- ShareAlike – If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
- No additional restrictions – You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
- You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
- No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
Go to https://creativecommons.org/licenses/by-nc-sa/4.0/ for more information.
Something has gone wrong in the attempt to record your agreement to the Open Access data use terms. If you are using a ConnectomeDB account, we recommend following these steps:
- Log out of BALSA
- Log into your ConnectomeDB account
- Locate any HCP data set
- Click on the 'Data Use Terms Required' button
- Accept the terms
- Log back into BALSA
We apologize for any inconvenience.
Multimodal 3D atlas of the macaque monkey inferior parietal lobe
Parcellation scheme of the macaque inferior parietal lobule projected onto the lateral view of the Yerkes19 surface (Donahue et al., 2016). 6 cyto- and receptor architectonically distinc areas were ideintified in this brain region: four areas are located at different caudo-rostral levels on the IPL convexity (from caudal to rostral, areas Opt, PG, PFG, and PF); two additional areas in the parietal operculum (areas PGop caudally and PFop rostrally). The absolute mean areal densities and laminar densities of receptors for glutamate (AMPA, kainate, NMDA), GABA (GABAA, GABAB, GABAA associated benzodiazepine (GABAA/BZ) binding sites), acetylcholine (M1, M2, M3), norepinephrine (alpha1, alpha2), serotonin (5-HT1A, 5-HT2), dopamine (D1) and adenosine (A1) have been projected onto the corresponding area. Color bars code for receptor densities in fmol/mg protein.
The macaque monkey inferior parietal lobe (IPL) is a structurally heterogeneous brain region, although the number of areas it contains and the anatomical/functional relationship of identified subdivisions remains controversial. Neurotransmitter receptor distribution patterns not only reveal the position of the cortical borders, but also segregate areas associated to different functional systems. Thus we carried out a multimodal quantitative analysis of the cyto- and receptor architecture of the macaque IPL to determine the number and extent of distinct areas it encompasses. We identified four areas on the IPL convexity arranged in a caudo-rostral sequence, as well as two areas in the parietal operculum, which we projected onto the Yerkes19 surface. We found rostral areas to have relatively smaller receptor fingerprints than the caudal ones, which is in an agreement with the functional gradient along the caudo-rostral axis described in previous studies. The hierarchical analysis segregated IPL areas into two clusters: the caudal one, contains areas involved in multisensory integration and visual-motor functions, and rostral cluster, encompasses areas active during motor planning and action-related functions. The results of the present study provide novel insights into clarifying the homologies between human and macaque IPL areas. The ensuing 3D map of the macaque IPL, and the receptor fingerprints are made publicly available to the neuroscientific community via the Human Brain Project and BALSA repositories for future cyto- and/or receptor architectonically driven analyses of functional imaging studies in non-human primates.
- Meiqi Niu
- Lucija Rapan
- Thomas Funck
- Sean Froudist-Walsh
- Ling Zhao
- Karl Zilles
- Nicola Palomero-Gallagher
- Heinrich-Heine University
- Research Centre Jülich
- Medical Faculty, RWTH Aachen
- New York University