FULL TITLE:
Extending the Human Connectome Project across ages: Imaging protocols for the Lifespan Development and Aging projects
SPECIES:
Human
ABSTRACT:
The Human Connectome Projects in Development (HCP-D) and Aging (HCP-A) are two large-scale brain imaging studies that will extend the recently completed HCP Young-Adult (HCP-YA) project to nearly the full lifespan, collecting structural, resting-state fMRI, task-fMRI, diffusion, and perfusion MRI in participants from 5 to 100+ years of age. HCP-D is enrolling 1300+ healthy children, adolescents, and young adults (ages 5-21), and HCP-A is enrolling 1200+ healthy adults (ages 36-100+), with each study collecting longitudinal data in a subset of individuals at particular age ranges. The imaging protocols of the HCP-D and HCP-A studies are very similar, differing primarily in the selection of different task-fMRI paradigms. We strove to harmonize the imaging protocol to the greatest extent feasible with the completed HCP-YA (1200+ participants, aged 22-35), but some imaging-related changes were motivated or necessitated by hardware changes, the need to reduce the total amount of scanning per participant, and/or the additional challenges of working with young and elderly populations. Here, we provide an overview of the common HCP-D/A imaging protocol including data and rationales for protocol decisions and changes relative to HCP-YA. The result will be a large, rich, multi-modal, and freely available set of consistently acquired data for use by the scientific community to investigate and define normative developmental and aging related changes in the healthy human brain.
PUBLICATION:
NeuroImage
- DOI:
10.1016/j.neuroimage.2018.09.060
- PMID:
30261308
- Michael P Harms
- Leah H Somerville
- Beau M Ances
- Jesper Andersson
- Deanna M Barch
- Matteo Bastiani
- Susan Y Bookheimer
- Timothy B Brown
- Randy L Buckner
- Gregory C Burgess
- Timothy S Coalson
- Michael A Chappell
- Mirella Dapretto
- Gwenaëlle Douaud
- Bruce Fischl
- Matthew F Glasser
- Douglas N Greve
- Cynthia Hodge
- Keith W Jamison
- Saad Jbabdi
- Sridhar Kandala
- Xiufeng Li
- Ross W Mair
- Silvia Mangia
- Daniel Marcus
- Daniele Mascali
- Steen Moeller
- Thomas E Nichols
- Emma C Robinson
- David H Salat
- Stephen M Smith
- Stamatios N Sotiropoulos
- Melissa Terpstra
- Kathleen M Thomas
- M Dylan Tisdall
- Kamil Ugurbil
- Andre van der Kouwe
- Roger P Woods
- Lilla Zöllei
- David C Van Essen
- Essa Yacoub