Study: Extending the Human Connectome Project across ages: Imaging protocols for the Lifespan Development and Aging projects

Extending the Human Connectome Project across ages: Imaging protocols for the Lifespan Development and Aging projects


The Human Connectome Projects in Development (HCP-D) and Aging (HCP-A) are two large-scale brain imaging studies that will extend the recently completed HCP Young-Adult (HCP-YA) project to nearly the full lifespan, collecting structural, resting-state fMRI, task-fMRI, diffusion, and perfusion MRI in participants from 5 to 100+ years of age. HCP-D is enrolling 1300+ healthy children, adolescents, and young adults (ages 5-21), and HCP-A is enrolling 1200+ healthy adults (ages 36-100+), with each study collecting longitudinal data in a subset of individuals at particular age ranges. The imaging protocols of the HCP-D and HCP-A studies are very similar, differing primarily in the selection of different task-fMRI paradigms. We strove to harmonize the imaging protocol to the greatest extent feasible with the completed HCP-YA (1200+ participants, aged 22-35), but some imaging-related changes were motivated or necessitated by hardware changes, the need to reduce the total amount of scanning per participant, and/or the additional challenges of working with young and elderly populations. Here, we provide an overview of the common HCP-D/A imaging protocol including data and rationales for protocol decisions and changes relative to HCP-YA. The result will be a large, rich, multi-modal, and freely available set of consistently acquired data for use by the scientific community to investigate and define normative developmental and aging related changes in the healthy human brain.

NeuroImage - DOI: 10.1016/j.neuroimage.2018.09.060 - PMID: 30261308

  • Michael P Harms
  • Leah H Somerville
  • Beau M Ances
  • Jesper Andersson
  • Deanna M Barch
  • Matteo Bastiani
  • Susan Y Bookheimer
  • Timothy B Brown
  • Randy L Buckner
  • Gregory C Burgess
  • Timothy S Coalson
  • Michael A Chappell
  • Mirella Dapretto
  • Gwenaëlle Douaud
  • Bruce Fischl
  • Matthew F Glasser
  • Douglas N Greve
  • Cynthia Hodge
  • Keith W Jamison
  • Saad Jbabdi
  • Sridhar Kandala
  • Xiufeng Li
  • Ross W Mair
  • Silvia Mangia
  • Daniel Marcus
  • Daniele Mascali
  • Steen Moeller
  • Thomas E Nichols
  • Emma C Robinson
  • David H Salat
  • Stephen M Smith
  • Stamatios N Sotiropoulos
  • Melissa Terpstra
  • Kathleen M Thomas
  • M Dylan Tisdall
  • Kamil Ugurbil
  • Andre van der Kouwe
  • Roger P Woods
  • Lilla Zöllei
  • David C Van Essen
  • Essa Yacoub