The relationship between spatial configuration and functional connectivity of brain regions
Figure 2: A: representative maps of the two extreme ends (identified based on the low and high extremes along a linearly spaced vector that spans the full range of subject CCA scores) of the CCA mode of population covariation continuum are shown for the default mode network (DMN, the PFM mode that contributed most strongly to the CCA mode of population covariation). The top row shows that the inferior parietal node of the DMN differs in shape and extends into the intraparietal sulcus in subjects who score high on the positive-negative CCA mode (left), compared with subjects who score lower (right). The bottom row shows that medial prefrontal and posterior cingulate/ precuneus regions of the DMN differ in size and shape as a function of the CCA positive-negative mode. The representative maps at both extremes are thresholded at ± 2 (arbitrary units specific to the PFM algorithm) for visualisation purposes (the differences are not affected by the thresholding; for unthresholded video-versions of these maps, please see the Supplementary video files which can be downloaded here to aid the review process: https://drive.google.com/drive/folders/0B6J0Q9KXPsNYWmlhTENpa3BKRmc?usp=sharing). The grey contours are identical on the left and right to aid visual comparison, and are based on the group-average maps (thresholded at 0.75). Spatial changes of all PFM modes can be seen in the Supplementary video files and in Figure 2-figure supplements 2-7. B: difference maps (positive - negative; thresholded at ± 1) are shown to aid comparison. C: A summary of topographic variability across all PFM modes, showing PFM correlations with CCA subject weights (at each grayordinate the maximum absolute r across all PFMs is displayed). An extended version of C is available in Figure 2-figure supplement 1. Data of figure 2 available at: https://balsa.wustl.edu/8lVx.
Surface Mesh:32k fs LR, Registration:MSMAll, Species:Human