map_macaque_somatosensory

map_macaque_somatosensory.scene

FULL TITLE:
Multimodal mapping of macaque monkey somatosensory cortex

SPECIES:
Macaque

DESCRIPTION:
The parcellation scheme of the macaque somatosensory cortex projected onto the lateral view of the Yerkes19 surface (Donahue et al., 2016). Thirteen cyto-/myelo- and receptor architectonically distinct areas were identified in this brain region: three subdivisions within the primary somatosensory cortex (i.e., 3bm, 3bli, 3ble), four within the anterior parietal cortex (i.e., 3am, 3al, 1 and 2) and six subdivisions (i.e., S2l, S2m, PVl, PVm, PRl and PRm) within the lateral fissure.

ABSTRACT:
The somatosensory cortex is a brain region responsible for receiving and processing sensory information from across the body and is structurally and functionally heterogeneous. Since the chemoarchitectonic segregation of the cerebral cortex can be revealed by transmitter receptor distribution patterns, we carried out a multimodal quantitative analysis of the cyto-/myelo- and receptor architecture of the macaque somatosensory cortex to analyze its molecular architectonic organization. We identified three architectonically distinct cortical entities within the primary somatosensory cortex (i.e., 3bm, 3bli, 3ble), four within the anterior parietal cortex (i.e., 3am, 3al, 1 and 2) and six subdivisions (i.e., S2l, S2m, PVl, PVm, PRl and PRm) within the lateral fissure. We provide a 3D atlas of macaque somatosensory areas in stereotaxic space, which integrates cyto- and receptor architectonic features of identified areas. Multivariate analyses of the receptor fingerprints revealed four clusters of identified areas based on the degree of (dis)similarity of their receptor architecture. Each of these clusters can be associated with distinct levels of somatosensory processing, further demonstrating that the functional segregation of cortical areas is underpinned by differences in their molecular organization.

PUBLICATION:
Progress in Neurobiology - DOI: 10.1016/j.pneurobio.2024.102633