Figure S2 (bottom row) Human folding variability - surface views
For humans (bottom row), individual differences in cortical folding are even more pronounced. The 210V group average midthickness surfaces aligned using cortical folding (‘MSMSulc’, third column) differ markedly from any individual in a region-specific manner. Near early sensory areas (e.g., the central sulcus), folding patterns are relatively consistent, and sulci are deep in the atlas surfaces. In highly variable cognitive regions, the average surface is smoother and intermediate in depth relative to individual-subject folds (blue and green vertices, arrows in the inferior parietal lobule). When intersubject registration is constrained by areal features based on myelin maps and functional MRI (fMRI) using ‘MSMAll’ (fourth column), the average midthickness surface is even smoother because cortical areas vary in location relative to cortical folds (Calson et al., PNAS, 2018). MSMSulc and MSMAll average midthickness surfaces both show high bilateral symmetry, which is critical for establishing left-right correspondences (Van Essen et al, Cerebral Cortex, 2012).
Surface Mesh:32k fs LR, Species:Chimpanzee, Species:Human, Registration:MSMAll, Species:Macaque, Atlas:Yerkes 19, Registration:MSMSulc