Study: The Detailed Organization of the Human Cerebellum Estimated by Intrinsic Functional Connectivity Within the Individual
National University of Singapore (NUS) and Harvard University Data Use Terms
1. I will not attempt to establish the identity of or attempt to contact any of the included human subjects.
2. I understand that under no circumstances will the code that would link these data to Protected Health Information be given to me, nor will any additional information about individual human subjects be released to me under these data use terms.
3. The released data is intended to be de-identified. I will comply with all relevant rules and regulations imposed by my institution. This may mean that I need my research to be approved or declared exempt by a committee that oversees research on human subjects, e.g. my IRB or Ethics Committee.
4. I may redistribute these original and any derived data as long as the data are re-distributed under these same data use terms and subject to the agreement of my IRB or Ethics Committee.
5. I will acknowledge the use of these data when publicly presenting any results or algorithms that benefitted from their use. Papers, book chapters, books, posters, oral presentations, and all other printed and digital presentations of results derived from this data should cite relevant papers associated with the data used, including the publication(s) associated with this BALSA study.
6. Failure to abide by these guidelines will result in termination of my privileges to access National University of Singapore and Harvard University data.
Something has gone wrong in the attempt to record your agreement to the Open Access data use terms. If you are using a ConnectomeDB account, we recommend following these steps:
- Log out of BALSA
- Log into your ConnectomeDB account
- Locate any HCP data set
- Click on the 'Data Use Terms Required' button
- Accept the terms
- Log back into BALSA
We apologize for any inconvenience.
The Detailed Organization of the Human Cerebellum Estimated by Intrinsic Functional Connectivity Within the Individual
Parcellations for both individuals and seed maps in the paper are included in this study. Code is available at https://github.com/ThomasYeoLab/CBIG/tree/master/stable_projects/
Distinct regions of the cerebellum connect to separate regions of the cerebral cortex forming a complex topography. While cerebellar organization has been examined in group-averaged data, study of individuals provides an opportunity to discover features that emerge at a higher spatial resolution. Here functional connectivity MRI was used to examine the cerebellum of two intensively-sampled individuals (each scanned 31 times). Connectivity to somatomotor cortex showed the expected crossed laterality and topography of the body maps. A surprising discovery was connectivity to the primary visual cortex along the vermis with evidence for representation of the central field. Within the hemispheres, each individual displayed a hierarchical progression from the inverted anterior lobe somatomotor map through to higher-order association zones. The hierarchy ended at Crus I/II and then progressed in reverse order through to the upright somatomotor map in the posterior lobe. Evidence for a third set of networks was found in the most posterior extent of the cerebellum. Detailed analysis of the higher-order association networks revealed robust representations of two distinct networks linked to the default network, multiple networks linked to cognitive control, as well as a separate representation of a language network. While idiosyncratic spatial details emerged between subjects, each network could be detected in both individuals, and seed regions placed within the cerebellum recapitulated the full extent of the spatially-specific cerebral networks. The observation of multiple networks in juxtaposed regions at the Crus I/II apex confirms the importance of this zone to higher-order cognitive function and reveals new organizational details.
Journal of Neurophysiology - DOI: 10.1152/jn.00561.2020
- Aihuiping Xue
- Ru Kong
- Qing Yang
- Mark C. Eldaief
- Peter Angeli
- Lauren M. DiNicola
- Rodrigo M. Braga
- Randy L. Buckner
- B.T. Thomas Yeo
- Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
- Department of Electrical and Computer Engineering, Centre for Sleep & Cognition, Centre for Translational Magnetic Resonance Research, N.1 Institute for Health and Institute for Digital Medicine, National University of Singapore, Singapore, 117574, Singapore
- Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
- NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, 117574, Singapore
- Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
- Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA